Apolipoprotein E4 in Patients with Alzheimer’s Disease in Slovak Region
Autor: Shahpesandy H., Habalová V., Kafka J., Kitková S., Dóci I., Kafková M., Medvecký M.
Many studies have found high frequency of ApoE e4 in patients with Alzheimer’s disease (AD). The aim of this study was to asses the risk of AD in relation to genetic polymorphism of ApoE gene in Slovak region. Methods: Study of 34 patients, all subjects met the ICD-10 criteria for AD. The polymorphism of ApoE gene was investigated by polymerase chain reaction and digestion with Afl III. Results: The ApoE e4 allele was found in 44.1% of patients (73% of them with late-onset AD, 27% with early-onset AD). The proportion of patients with non-ApoE e4 was 55.9%. Conclusion: The frequency of patients with ApoE e4 in Slovak region is slink to the common results of western studies and confirms the role of ApoE e4 allele as a risk factor for AD (Fig. 2, Tab. 1, Ref. 40).
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